2024年12月21日 (六) 14:07 长河

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Interaction of nuclear
import receptors with FG repeats.
Left: Nuclear import receptors contain
various low-affinity FG repeat–binding
sites on their surface. This facilitates
their initial recruitment to NPCs because
of interactions with FG repeats found
on the cytosolic fibrils of the NPCs. The
interior of the NPC is filled with a mesh
of FG repeat–containing proteins whose
weak interactions with each other restrict
nonspecific diffusion of proteins and other
macromolecules through the pore. Right:
Cargo receptors can rapidly partition into
the FG repeat mesh by interacting with
the FG repeats and locally melting the
mesh. This partitioning into and out of the
mesh substantially accelerates diffusion of
the cargo receptor (and its bound cargo)
through the NPC. Proteins without surface
FG repeat–binding sites cannot melt the
mesh, and their diffusion through the NPC
is comparatively slow.

文件:细胞12.59.png - 版本历史

2024年12月21日 (六) 14:07 长河