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<p></p> <p><b>新页面</b></p><div>Endosome maturation: <br /> the endocytic pathway from the plasma <br /> membrane to lysosomes. Near the cell <br /> periphery, endocytic vesicles fuse with <br /> an early endosome, which is the primary <br /> sorting station. Tubular portions of the early <br /> endosome bud off vesicles that recycle <br /> endocytosed cargo back to the plasma <br /> membrane—either directly or indirectly <br /> via recycling endosomes. Recycling <br /> endosomes can store proteins until they are <br /> needed. Conversion of early endosomes to <br /> late endosomes is accompanied by loss of <br /> the tubular projections. Membrane proteins <br /> destined for degradation are internalized <br /> in intralumenal vesicles. The developing <br /> late endosome, or multivesicular body, <br /> moves on microtubules to the cell interior. <br /> Fully matured late endosomes no longer <br /> send vesicles to the plasma membrane, <br /> and they fuse with one another and with <br /> endolysosomes and lysosomes to degrade <br /> their contents. Each stage of endosome <br /> maturation is connected to the TGN via <br /> transport vesicles, providing a continual <br /> supply of newly synthesized lysosomal <br /> proteins.</div>

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