https://osm.bio/index.php?action=history&feed=atom&title=%E8%A1%80%E7%BA%A2%E8%9B%8B%E7%99%BD%E4%B8%8EHb%E7%9B%B8%E5%85%B3%E7%96%BE%E7%97%85 2026-05-14T23:59:24Z 本wiki上该页面的版本历史 MediaWiki 1.45.1 https://osm.bio/index.php?title=%E8%A1%80%E7%BA%A2%E8%9B%8B%E7%99%BD%E4%B8%8EHb%E7%9B%B8%E5%85%B3%E7%96%BE%E7%97%85&diff=11276&oldid=prev 2025-08-23T08:35:55Z

<p>自动添加 Sofia 模板和分类</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年8月23日 (六) 16:35的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l38">第38行：</td> <td colspan="2" class="diff-lineno">第38行：</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;nowiki&gt;*&lt;/nowiki&gt;可以用丁酸治疗，即增加HbF的表达（无β链）</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>&lt;nowiki&gt;*&lt;/nowiki&gt;可以用丁酸治疗，即增加HbF的表达（无β链）</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{学科分类}}</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:生物化学]]</ins></div></td></tr> </table>

Sofia https://osm.bio/index.php?title=%E8%A1%80%E7%BA%A2%E8%9B%8B%E7%99%BD%E4%B8%8EHb%E7%9B%B8%E5%85%B3%E7%96%BE%E7%97%85&diff=11090&oldid=prev 2025-08-23T07:57:43Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年8月23日 (六) 15:57的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">第1行：</td> <td colspan="2" class="diff-lineno">第1行：</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== 血红蛋白的基因 ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== 血红蛋白的基因 ==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:生物化学]]</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=== α基因簇-位于16p13.3 ===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=== α基因簇-位于16p13.3 ===</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ζ-ψζ-αD-ψα-α2-α1-θ</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ζ-ψζ-αD-ψα-α2-α1-θ</div></td></tr> </table>

Magezeya https://osm.bio/index.php?title=%E8%A1%80%E7%BA%A2%E8%9B%8B%E7%99%BD%E4%B8%8EHb%E7%9B%B8%E5%85%B3%E7%96%BE%E7%97%85&diff=4923&oldid=prev 2025-03-18T02:19:34Z

<p><span class="autocomment">β基因簇-位于</span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年3月18日 (二) 10:19的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l4">第4行：</td> <td colspan="2" class="diff-lineno">第4行：</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ζ-ψζ-αD-ψα-α2-α1-θ</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ζ-ψζ-αD-ψα-α2-α1-θ</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>=== β基因簇-<del style="font-weight: bold; text-decoration: none;">位于 </del>===</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>=== β基因簇-<ins style="font-weight: bold; text-decoration: none;">位于11p15.2 </ins>===</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ε-Gγ-Aγ-ψβ-δ-β</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ε-Gγ-Aγ-ψβ-δ-β</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> </table>

-光追- https://osm.bio/index.php?title=%E8%A1%80%E7%BA%A2%E8%9B%8B%E7%99%BD%E4%B8%8EHb%E7%9B%B8%E5%85%B3%E7%96%BE%E7%97%85&diff=4340&oldid=prev 2025-03-07T02:49:17Z

<p><span class="autocomment">血红蛋白的结构</span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年3月7日 (五) 10:49的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l33">第33行：</td> <td colspan="2" class="diff-lineno">第33行：</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* HbH：β4</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* HbH：β4</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Hb Barts：γ4</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Hb Barts：γ4</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">=== 镰状红细胞贫血 ===</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">β链上6号位Glu突变成Val，易相互聚集成纤维，导致细胞变性和破裂</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;nowiki&gt;*&lt;/nowiki&gt;可以用丁酸治疗，即增加HbF的表达（无β链）</ins></div></td></tr> </table>

N·CHEN·Y https://osm.bio/index.php?title=%E8%A1%80%E7%BA%A2%E8%9B%8B%E7%99%BD%E4%B8%8EHb%E7%9B%B8%E5%85%B3%E7%96%BE%E7%97%85&diff=1773&oldid=prev 2024-10-26T09:59:35Z

<p>创建页面，内容为“== 血红蛋白的基因 == === α基因簇-位于16p13.3 === ζ-ψζ-αD-ψα-α2-α1-θ === β基因簇-位于 === ε-Gγ-Aγ-ψβ-δ-β 假基因ψ已经失活，不能表达蛋白质；αD和θ的表达产物尚未发现。 == 血红蛋白的结构 == 人类主要产生五种血红蛋白亚基： α、ζ链有146个残基，β、γ、δ链有141个残基。 * 胚胎时期，第四周开始，卵黄囊中，产生的血红蛋白有： ** Gower 1 (ζ&lt;su…”</p> <p><b>新页面</b></p><div>== 血红蛋白的基因 ==<br /> <br /> === α基因簇-位于16p13.3 ===<br /> ζ-ψζ-αD-ψα-α2-α1-θ<br /> <br /> === β基因簇-位于 ===<br /> ε-Gγ-Aγ-ψβ-δ-β<br /> <br /> 假基因ψ已经失活，不能表达蛋白质；αD和θ的表达产物尚未发现。<br /> <br /> == 血红蛋白的结构 ==<br /> 人类主要产生五种血红蛋白亚基：<br /> <br /> α、ζ链有146个残基，β、γ、δ链有141个残基。<br /> <br /> * 胚胎时期，第四周开始，卵黄囊中，产生的血红蛋白有：<br /> ** Gower 1 (ζ&lt;sub&gt;2&lt;/sub&gt;ε&lt;sub&gt;2&lt;/sub&gt;).<br /> ** Gower 2 (α&lt;sub&gt;2&lt;/sub&gt;ε&lt;sub&gt;2&lt;/sub&gt;).<br /> ** Portland I 血红蛋白(ζ&lt;sub&gt;2&lt;/sub&gt;γ&lt;sub&gt;2&lt;/sub&gt;).<br /> ** Portland II 血红蛋白(ζ&lt;sub&gt;2&lt;/sub&gt;β&lt;sub&gt;2&lt;/sub&gt;).<br /> * 胎儿时期，第十周开始，肝脏脾脏中，产生：<br /> ** 胎儿血红蛋白HbF(α2γ2)<br /> * 成体，骨髓中，产生：<br /> ** 血红蛋白A-HbA:α2β2 （&gt;95％）<br /> ** 血红蛋白A2-HbA2：α2δ2<br /> ** HbF(α2γ2)<br /> <br /> == 有关血红蛋白的疾病 ==<br /> <br /> === α地中海贫血 ===<br /> 两条染色体上4个α基因部分或全部缺失，导致α亚基不能产生/产生减少。患者体内含有：<br /> <br /> * HbH：β4<br /> * Hb Barts：γ4</div>

长河