查看“︁文件:细胞19-12.png”︁的源代码

Mechanotransduction in 
an adherens junction. Cell–cell junctions 
are able to sense increased tension and 
respond by strengthening their actin 
linkages. When actin filaments are pulled 
from within the cell by non-muscle myosin 
II, the resulting force unfolds a domain in 
α-catenin, thereby exposing an otherwise 
hidden binding site for the adaptor  
protein vinculin. Vinculin then promotes 
additional actin recruitment, strengthening 
the linkages between the junction and  
the cytoskeleton