内膜系统运输:修订间差异

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创建页面,内容为“== 一.衔接蛋白 == 衔接蛋白有两类:AP1-5和GGA1-3. AP复合体都是异四聚体,有五种,组成为(β)+(α/γ/δ/ε/ζ)+(μ)+(σ)”
 
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AP复合体都是异四聚体,有五种,组成为(β)+(α/γ/δ/ε/ζ)+(μ)+(σ)
AP复合体都是异四聚体,有五种,组成为(β)+(α/γ/δ/ε/ζ)+(μ)+(σ)
{| class="wikitable"
! Adapter !! Large Subunit !! Localization !! Sorting Motif !! Coat Protein !! Phospholipid !! Small GTPase !! Function
|-
| AP-1 || γ1/2, β1, μ1A/B, σ1A/B/C || TGN/endosomes || YXXØ, [DE]XXXL[LI] || Clathrin || PI4P? || Arf-1 || TGN↔endosomes, Polarized sorting
|-
| AP-2 || αA/C, β2, μ2, σ2 || Plasma membrane || YXXØ, [DE]XXXL[LI] || Clathrin || PIP2 || Arf-6? || Clathrin-dependent endocytosis
|-
| AP-3 || δ, β3A/B, μ3A/B, σ3A/B || Endosomes || YXXØ, [DE]XXXL[LI] || Clathrin? || Unknown || Arf-1 || LRO biogenesis
|-
| AP-4 || ε, β4, μ4, σ4 || TGN || YX[FYL][FL]E || Unknown || Unknown || Arf-1 || TGN→endosomes, Polarized sorting
|-
| AP-5 || ζ, β5, μ5, σ5 || Late endosomes || Unknown || SPG11/SPG15? || PI3P? || Unknown || Unknown
|}

2025年1月6日 (一) 10:41的版本

一.衔接蛋白

衔接蛋白有两类:AP1-5和GGA1-3.

AP复合体都是异四聚体,有五种,组成为(β)+(α/γ/δ/ε/ζ)+(μ)+(σ)

Adapter Large Subunit Localization Sorting Motif Coat Protein Phospholipid Small GTPase Function
AP-1 γ1/2, β1, μ1A/B, σ1A/B/C TGN/endosomes YXXØ, [DE]XXXL[LI] Clathrin PI4P? Arf-1 TGN↔endosomes, Polarized sorting
AP-2 αA/C, β2, μ2, σ2 Plasma membrane YXXØ, [DE]XXXL[LI] Clathrin PIP2 Arf-6? Clathrin-dependent endocytosis
AP-3 δ, β3A/B, μ3A/B, σ3A/B Endosomes YXXØ, [DE]XXXL[LI] Clathrin? Unknown Arf-1 LRO biogenesis
AP-4 ε, β4, μ4, σ4 TGN YX[FYL][FL]E Unknown Unknown Arf-1 TGN→endosomes, Polarized sorting
AP-5 ζ, β5, μ5, σ5 Late endosomes Unknown SPG11/SPG15? PI3P? Unknown Unknown