内膜系统运输:修订间差异
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创建页面,内容为“== 一.衔接蛋白 == 衔接蛋白有两类:AP1-5和GGA1-3. AP复合体都是异四聚体,有五种,组成为(β)+(α/γ/δ/ε/ζ)+(μ)+(σ)” |
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AP复合体都是异四聚体,有五种,组成为(β)+(α/γ/δ/ε/ζ)+(μ)+(σ) | AP复合体都是异四聚体,有五种,组成为(β)+(α/γ/δ/ε/ζ)+(μ)+(σ) | ||
{| class="wikitable" | |||
! Adapter !! Large Subunit !! Localization !! Sorting Motif !! Coat Protein !! Phospholipid !! Small GTPase !! Function | |||
|- | |||
| AP-1 || γ1/2, β1, μ1A/B, σ1A/B/C || TGN/endosomes || YXXØ, [DE]XXXL[LI] || Clathrin || PI4P? || Arf-1 || TGN↔endosomes, Polarized sorting | |||
|- | |||
| AP-2 || αA/C, β2, μ2, σ2 || Plasma membrane || YXXØ, [DE]XXXL[LI] || Clathrin || PIP2 || Arf-6? || Clathrin-dependent endocytosis | |||
|- | |||
| AP-3 || δ, β3A/B, μ3A/B, σ3A/B || Endosomes || YXXØ, [DE]XXXL[LI] || Clathrin? || Unknown || Arf-1 || LRO biogenesis | |||
|- | |||
| AP-4 || ε, β4, μ4, σ4 || TGN || YX[FYL][FL]E || Unknown || Unknown || Arf-1 || TGN→endosomes, Polarized sorting | |||
|- | |||
| AP-5 || ζ, β5, μ5, σ5 || Late endosomes || Unknown || SPG11/SPG15? || PI3P? || Unknown || Unknown | |||
|} |
2025年1月6日 (一) 10:41的版本
一.衔接蛋白
衔接蛋白有两类:AP1-5和GGA1-3.
AP复合体都是异四聚体,有五种,组成为(β)+(α/γ/δ/ε/ζ)+(μ)+(σ)
Adapter | Large Subunit | Localization | Sorting Motif | Coat Protein | Phospholipid | Small GTPase | Function |
---|---|---|---|---|---|---|---|
AP-1 | γ1/2, β1, μ1A/B, σ1A/B/C | TGN/endosomes | YXXØ, [DE]XXXL[LI] | Clathrin | PI4P? | Arf-1 | TGN↔endosomes, Polarized sorting |
AP-2 | αA/C, β2, μ2, σ2 | Plasma membrane | YXXØ, [DE]XXXL[LI] | Clathrin | PIP2 | Arf-6? | Clathrin-dependent endocytosis |
AP-3 | δ, β3A/B, μ3A/B, σ3A/B | Endosomes | YXXØ, [DE]XXXL[LI] | Clathrin? | Unknown | Arf-1 | LRO biogenesis |
AP-4 | ε, β4, μ4, σ4 | TGN | YX[FYL][FL]E | Unknown | Unknown | Arf-1 | TGN→endosomes, Polarized sorting |
AP-5 | ζ, β5, μ5, σ5 | Late endosomes | Unknown | SPG11/SPG15? | PI3P? | Unknown | Unknown |